Interested in some 3D programming? Now you can use Open GL from VB.NET very easily, thanks to the CsGL library [CSGL Homepage]/ - which is a set of classes which wraps Open GL to use it from .NET. You may download the CsGL library binaires from here
If you need to grab some object oriented concepts in VB.NET, before you begin, have a look at my VB.NET article here.
Also, have a look at an interesting article here at OnDotNet.com, for a detailed discussion regarding using Open GL with VB.NET